BasePair Biotechnologies and the Power of Aptamer Discovery

In the realm of biotechnology, innovation is key to solving complex challenges and empowering advancements in healthcare and environmental preservation. Among the frontrunners in this field, BasePair Biotechnologies, Inc. stands tall as a world-leading provider of highly customized aptamer discovery and development services. With a profound mission to make a lasting difference in the world, BasePair Biotechnologies is revolutionizing the biotech landscape by creating novel affinity agents that empower healthcare solutions and protect our planet.

Experience: Pioneering Advancements in Aptamer Development

Base Pair Biotechnologies has been at the forefront of aptamer development and selection for over a decade. With a team of dedicated scientists who have led numerous grant-funded and customer-funded projects, the company has amassed a wealth of experience in developing aptamers for a wide range of applications. These applications include ELASA, fluorescence microscopy, fluorogenic solution-based assays, small molecule in vivo imaging, in vivo and in vitro biosensors, lateral flow, affinity resins, and scaffolds for three-dimensional tissue culture/regeneration.

Technology: Proprietary Innovations Driving Aptamer Excellence

At the core of Base Pair Biotechnologies’ success lies their robust intellectual property portfolio, which includes issued and pending patents as well as trade secrets related to aptamer selection, screening, and sequences. The company’s patented multiplex selection process significantly reduces time and cost for aptamer discovery, enabling the development of specific- and pan-binders to related targets. Base Pair’s proprietary aptamer libraries, with novel modifications and increased conformational diversity, further enhance binding properties. Moreover, the company employs state-of-the-art methods to develop aptamers for small molecules and determine solution phase affinity. Additionally, Base Pair has developed proprietary techniques for identifying aptamer sandwich pairs for ELASA and lateral flow methods.

Custom Aptamer Discovery & Development

Tailored Solutions for Unique Needs Recognizing that optimal aptamer performance is achieved under selection conditions, Base Pair recommends custom development projects for specialized assays or use conditions. The company’s custom aptamer discovery and development service is highly tailored to meet each customer’s unique requirements. By engaging in thorough consultations and designing detailed plans aligned with the project’s goals and objectives, Base Pair ensures the delivery of exceptional aptamer-based solutions.

Bioinformatics for Aptamer Selection

Unleashing the Power of Data Aptamer discovery is a complex process, requiring the identification of the best candidates from millions of potential sequences. Base Pair’s expertise in bioinformatics plays a pivotal role in this endeavor. By utilizing proprietary techniques and next-generation sequencing, the company evaluates up to 10 million sequences to identify top candidates. Factors such as sequence length, frequency count, predicted stability, and sequence motifs are carefully analyzed and provided in a detailed bioinformatics report. Furthermore, Base Pair employs Venn diagram analysis to identify individual- and pan-binders to multiple targets, leveraging their patented multiplex selection.

Partnering With Base Pair: Your Gateway to Aptamer Excellence

Choosing Base Pair Biotechnologies as your aptamer discovery and development partner offers unparalleled advantages. With over 50 years of combined experience in aptamer discovery and applications development, the entire team is committed to delivering the best possible aptamer-based solutions. Here’s why Base Pair should be your go-to partner:

Consultative Approach. Base Pair scientists thoroughly understand your needs, objectives, and requirements, ensuring a comprehensive project design. Their expertise and exclusive AptaTracker™ platform facilitate seamless communication throughout the project.

Customized Solutions. Recognizing the diversity of aptamer discovery projects, Base Pair selects from a portfolio of proprietary aptamer libraries and designs specialized libraries to match specific target characteristics and end-use applications. Their tailored approach ensures optimal aptamer design for each project.

Multiplex Aptamer Selection. Base Pair’s VENNmultiplex SELEX™ method enables simultaneous selection of aptamers for up to 30 targets, saving time and cost while ensuring competitive binding. Their complex Venn diagram analysis allows for the identification of aptamers specific to individual targets, pan-binders to related families, and aptamers with binding to specific subsets of targets.

Advanced Aptamer Modification. Base Pair offers aptamer modification techniques to further enhance affinity, stability, solubility, or detection. Aptamers can be “matured” through focused libraries, nuclease-blocking technology, or sequence modifications to improve performance.

Functional Aptamer Testing & Aptamer Pairs. Base Pair evaluates aptamers under end-use conditions to ensure compatibility and success in real-world applications. They also excel in identifying matched aptamer pairs for ELISA-like assays, lateral flow assays, and other applications.

Small Molecule Expertise. With their proprietary methods, Base Pair has successfully developed aptamers for selective recognition of non-immunogenic and toxic small molecules. Their techniques facilitate solubilization, presentation, and accurate measurement of aptamer affinity for small molecule targets.

Commercial Use Rights. Base Pair offers guidance and support in managing aptamer sequences, intellectual property, and patents, ensuring the protection of your research and business interests.

Base Pair Biotechnologies, with its profound expertise, cutting-edge technology, and customized solutions, is revolutionizing the biotech industry. Through their unwavering commitment to solving customer problems and creating novel affinity agents, Base Pair is empowering healthcare solutions and safeguarding our planet. Partnering with Base Pair Biotechnologies opens up a world of possibilities in the realm of aptamer discovery and development, setting the stage for groundbreaking advancements in biotechnology.

Engr. Dex Marco Tiu Guibelondo, BS Pharm, RPh, BS CpE

Editor-in-Chief, PharmaFEATURES