Medicinal Chemistry & Pharmacology
Generative Chemistry: The Artificial Intelligence Revolution in Drug Discovery
AI algorithms now design molecules from scratch, optimizing pharmacological profiles through iterative learning.
Artificial Proteins: Designing Life from Scratch
AI-driven de novo protein design is transforming the way scientists approach molecular engineering.
Machine Learning for Polaritonic Chemistry: Unbolting Chemical Kinetics Through Strong Light–Matter Coupling
Polaritonic chemistry steers, inhibits, and catalyzes chemical processes at room temperature, controlled by parameters like cavity mirror spacing.
Antibiotic Delivery 2.0: The Rise of Bio-Based Polymeric Microparticles
The encapsulation of norfloxacin in PEBSA-based microparticles marks a transformative development in antibiotic delivery.
Osteopontin: A Molecular Key to Cancer Drug Resistance
Targeting osteopontin could redefine the landscape of cancer therapy, transforming resistance into a treatable challenge.
Silencing Tumors: The Next Frontier in siRNA Delivery
Histidine-lysine (HK) peptides could transform siRNA therapeutics, enabling personalized cancer care and tackling untreatable conditions.
Ferroptosis, Apoptosis, Autophagy, Antiproliferation: TG1’s Quadruple-Targeting Mechanisms of Action Against Colorectal Cancer
By targeting ferroptosis, apoptosis, and autophagy while modulating MYC, TG1 disrupts the intricate survival networks of CRC cells.
Insulin Resistance: Bridging Peripheral Metabolism and Brain Function
Despite advances, key gaps in understanding insulin resistance persist, including CNS diagnostics, brain-periphery interactions, and apoE isoform roles, highlighting critical research priorities for new treatments.
Steroids and Bones: How Glucocorticoids Hijack Muscle Repair After Spinal Cord Injury
As medicine moves toward precision approaches, the role of glucocorticoids in trauma care warrants careful reconsideration.
Golden Precision: The Rise of Nano-Engineered Drug Delivery Systems
In the era of precision medicine, the golden age of nanotechnology is just beginning.
Alcohol Use Disorders: Genetic and Molecular Mechanisms Behind Problematic Drinking Behaviors
As our understanding of AUD’s genetic and molecular landscape deepens, so does the potential for innovative treatments that go beyond traditional approaches.
Advancing Precision Medicine: Protein Engineering and Nanoparticle Delivery in Modern Therapeutics
The precise delivery of therapeutic proteins is no longer just an aspiration—it is an urgent requirement in the development of next-generation treatments.
Breaking Cellular Barriers: Boron Cluster-Based Intracellular Protein Delivery for Next-Gen Therapeutics
Boron cluster-based molecular carriers like IBC-Pr may pave the way for a new generation of intracellular delivery systems that overcome the limitations of traditional approaches.
Precision Control of Oxidative Stress in Wound Healing and Inflammation
DHKNase-6 represents a paradigm shift in ROS-targeted therapies
Glucagon-Responsive Micelles for Hypoglycemia Prevention
The exploration of glucagon-responsive micelles and polymer conjugates offers a promising advancement in the field of diabetes management.
Targeted Liposomal Nanocarriers: Promising Shift in Drug Delivery Paradigms
Targeted liposomal therapeutics mark a shift toward precise and less toxic disease treatments.