Medicinal Chemistry & Pharmacology
Breaking Boundaries: The AI Revolution in Modern Lead Discovery
The introduction of computational methods into drug discovery marked a profound shift in the pharmaceutical and biotech industries.
Permeating the Cranial Center: Novel Nanoparticles for Neurodegeneration
Nanocarriers have demonstrated high effectiveness in delivering drugs and genes to the brain due to their unique properties.
Synthetic Chemistry’s Potential in Deciphering Antimicrobial Peptides
The saga of antimicrobial peptides unfolds as a testament to scientific ingenuity and therapeutic resilience.
Appreciating the Therapeutic Versatility of the Adenine Scaffold: From Biological Signaling to Disease Treatment
Researchers are utilizing adenine analogs to create potent inhibitors and agonists, targeting vital cellular pathways from cancer to infectious diseases.
Bioavailability and Bioequivalence: The Makings of Similar and “Close Enough” Drug Formulations
Scientists are striving to understand bioavailability complexities to ensure the equivalence of drug formulations from different manufacturers, crucial for clinical effectiveness.
Primer on Applied Biopharmaceutics and Pharmacokinetics: Part III
In the third part of the Biopharm and PK PharmaFEATURES Primer, we take a deeper dive in mathematical modeling to better estimate drug dosing and generate better predictions of drug efficacy vs time of medications.
Bioavailability: Deciphering the Dynamics of Drug Absorption and Distribution
Bioavailability, fundamental in pharmacology, explores intricate drug absorption and distribution in the body.
Primer on Applied Biopharmaceutics and Pharmacokinetics: Part II
Plasma drug concentrations monitoring allows medication dose adjustment for individualized and optimized drug therapies.
Balancing Act: Optimizing Physicochemical Properties for Successful Drug Discovery
A drug’s physicochemical properties play a crucial role in their effectiveness and safety.
QSAR Modeling Improves Understanding of Serotonin Neuropharmacology
QSAR promises to improve serotonin studies.
Navigating Drug Toxicity: Insights into Pharmacological Peril
Understanding drug toxicity mechanisms is vital for patient safety and treatment efficacy.
Target Locked, Hit Confirmed: A Drug Discovery Mission Possible
The path from target identification to hit discovery showcases the scientific community’s ingenuity and perseverance.
Fragment-Based Drug Discovery: A Comprehensive Overview
This FBDD article discusses its fundamental principles, workflow, library selection criteria, expansion strategies, and optimization approaches.
The So-Needed Revolution: Advanced Technologies in Cancer Biomedical Discovery
Let’s explore how advanced technologies are actively transforming biomedical discovery, particularly in cancer research.