Medicinal Chemistry & Pharmacology

Medicinal Chemistry & Pharmacology March 16, 2022

Chemoproteomics in Phenotypic Drug Discovery

Chemoproteomics is a natural complement of phenotypic drug discovery. We examine developments in the area and its future potentials.

Medicinal Chemistry & Pharmacology March 8, 2022

PROTACs Enter the Clinic: A Brief History

PROTACs have been a promising new treatment modality for years – we examine their recent history and innovations that show their potential

Medicinal Chemistry & Pharmacology March 3, 2022

The Rise of Multispecific Drugs

Multispecific drugs promise to be one of the big waves of innovation in pharma – we examine the main modalities and their impact.

Medicinal Chemistry & Pharmacology February 28, 2022

February 2022 Drug Launch Roundup

Highlights from drug launches in February 2022 – including controversy around Ruzurgi, and new orphan drugs.

Medicinal Chemistry & Pharmacology January 31, 2022

January 2022 Drug Launch Roundup

A summary of the highlights in new drug approvals that happened in January 2022, including new JAKs and therapies for cancer, endocrine disorders and eczema.

Featured October 7, 2021

The Pharmaceutical Applications of Chiral Chemicals

The growing importance of chirality in 3D chemical space exploration demonstrates a shift in modern drug discovery for hit-to-lead.

Featured September 16, 2021

Emerging Tools and Next Generation Biophysics in Drug Discovery

Biophysical techniques are an important tool in drug discovery, and emerging novel techniques have the potential to offer new advantages.

Medicinal Chemistry & Pharmacology September 7, 2021

Synthetic and Natural Polymers: Advancements in Drug Delivery and Medicine

Polymeric gene delivery systems is an exciting area of research, and could see the development of an innovative non-viral vector delivery.

Featured August 31, 2021

Exploring the Role of Nuclear Magnetic Resonance Spectroscopy in Drug Discovery

Nuclear magnetic resonance spectroscopy is becoming increasingly prevalent in drug discovery, especially so in fragment-based drug design.

Medicinal Chemistry & Pharmacology August 10, 2021

How Can Microcrystal Electron Diffraction Advance Drug Development?

MicroED can accelerate drug development and determine molecular structure quickly. Despite slow adoption, pharma is increasingly using it in studies.

Drug Discovery Biology June 16, 2021

Evaluating Advancements in Drug Discovery

Innovations in medicinal chemistry have seen significant developments in drug discovery. Fragment screening is a prime example.

Medicinal Chemistry & Pharmacology May 28, 2021

Emerging Therapeutics in Translational Medicine: Nanotechnology

Nanotechnology offers a number of advantages for biological research: Bone tissue regeneration and drug delivery systems are prime examples.

Medicinal Chemistry & Pharmacology May 7, 2021

Targeting RNA: A Key Part of Disease Research and Therapeutic Developments

The latest success of the mRNA COVID-19 vaccine and discovery of RNA targets in HIV are some of the many positive outcomes with RNA research.

Drug Discovery Biology April 19, 2021

Preclinical Pharmacokinetics: Solving the Problems of Early-Stage Predictive Assays

Pharmacokinetic assays are critical in selecting drug candidates. Recent innovations hope to overcome current preclinical challenges.

Medicinal Chemistry & Pharmacology April 13, 2021

Discovering Novel Chemical Entities with DNA-Encoded Libraries: Promises and Pitfalls

DNA-encoded libraries are a critical part of drug discovery. Recent advancements show great innovation and integration of machine learning.

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Inside Johnson & Johnson’s External Innovation Engine: Devin Swanson on Translating Integrated Discovery into Strategic Value

From Data to Decision: Shicheng Guo’s Systems Approach to AI-Enabled Drug Development

Digital Stewardship: Governing Access, Transparency, and Accountability in Clinical Data Warehouses