Genomics and Beyond with Parse Biosciences

Parse Biosciences is a biotechnology company founded in 2018 by a group of scientists who wanted to transform gene expression profiling with a simple, efficient, and precise approach. The company’s mission is to empower scientists to make breakthrough discoveries by offering innovative, accessible, and reliable products that provide deep insights into gene expression, cell type identification, and spatial transcriptomics.

Company Ethos

Parse Biosciences’ ethos is rooted in scientific rigor, transparency, and collaboration. The company believes that progress in biomedicine requires a community of researchers working together to overcome complex challenges. Parse Biosciences aims to provide scientists with the tools they need to accelerate their research and achieve their goals.

Product Portfolio

The company’s portfolio of products includes several cutting-edge technologies designed to enable gene expression analysis at single-cell resolution. Parse Biosciences’ flagship product is the One-Step Seq method, a streamlined workflow that simplifies RNA sequencing library preparation and reduces experimental variability. One-Step Seq has been shown to produce accurate and reproducible results in diverse sample types, including cultured cells, fresh tissues, and formalin-fixed paraffin-embedded (FFPE) specimens.

In addition to One-Step Seq, Parse Biosciences offers several other products that address different research needs. Parse Cell (formerly known as MARS-Seq) is a cell type identification kit that enables researchers to map the transcriptomic landscape of complex tissues and identify rare cell populations. Parse Spatial is a spatial transcriptomics kit that provides high-resolution spatial information on gene expression patterns in tissue sections. Parse Biosciences also offers custom services for sample processing, library preparation, and sequencing.

Beyond the Conventional Droplet Technologies

Parse Biosciences’ technology is based on a unique barcoding approach that allows researchers to label individual cells or spatial locations with a unique DNA tag. This approach enables the analysis of thousands of cells or tissue regions in a single experiment, providing unprecedented insights into gene expression and cellular diversity. Parse Biosciences’ methods are compatible with multiple sequencing platforms, including Illumina and Oxford Nanopore, and can be adapted to various sample types and experimental designs.

The impact of Parse Biosciences’ technology has been demonstrated in numerous publications, where it has been used to address diverse research questions, from cancer biology to neuroscience to developmental biology. Parse Biosciences has also collaborated with academic and industry partners to develop new applications and expand the scope of its technology.

Parse Biosciences’ Evercode™

The Evercode™ combinatorial barcoding technology is a key component of Parse Biosciences’ innovative approach to gene expression profiling. This technology enables high-resolution gene expression analysis at single-cell and spatial resolution by allowing researchers to label individual cells or spatial locations with a unique DNA tag.

The Evercode™ technology is based on a library of millions of unique DNA sequences that can be combined in different ways to create custom barcodes. By combining multiple barcodes, researchers can label thousands of individual cells or spatial locations with a unique identifier, enabling the analysis of complex biological systems with high accuracy and reproducibility.

One of the advantages of the Evercode™ technology is its flexibility. The library of DNA sequences can be customized to match the needs of specific experiments, and the barcodes can be adapted to different sequencing platforms and sample types. This allows researchers to use the same technology for a wide range of applications, from single-cell RNA sequencing to spatial transcriptomics analysis.

Another advantage of the Evercode™ technology is its simplicity. The technology requires only a small amount of starting material, and the workflow can be streamlined to reduce experimental variability and increase throughput. This makes the technology accessible to a wide range of researchers, from basic scientists to clinical researchers.

The Evercode™ technology has been shown to produce highly reproducible and accurate results in a variety of sample types, including cultured cells, fresh tissues, and FFPE specimens. By harnessing the power of combinatorial barcoding, Parse Biosciences’ technology is enabling researchers to make breakthrough discoveries in fields such as cancer biology, immunology, neuroscience, and developmental biology.

Genomics and Beyond

Parse Biosciences is a leading biotechnology company that is revolutionizing gene expression profiling with its innovative Evercode™ combinatorial barcoding technology. Its flexible, high-throughput approach enables researchers to analyze complex biological systems with high accuracy and reproducibility, making it an essential tool for basic and clinical research. With its commitment to innovation and excellence, Parse Biosciences is poised to make a major impact on the field of genomics and beyond.

More about Parse Biosciences on parsebiosciences.com.

Engr. Dex Marco Tiu Guibelondo, BS Pharm, RPh, BS CpE

Editor-in-Chief, PharmaFEATURES