On 26 July 2021, Kiromic Biopharma announced the completed acquisition of InSilico Solutions. The agreement will leverage the bioinformatics and artificial intelligence capacities of InSilico Solutions to advance the clinical development of Kiromic’s CAR-T for solid tumours.
While the financial terms have not been disclosed, the deal will involve a stock swap in addition to Kiromic hiring the entire InSilico staff. Interestingly enough, the companies have been collaborating for three years prior to the acquisition, working on a highly effective system of analysing genomic data for the best possible biomarkers for targeted immunotherapy.
The recent acquisition hopes to make significant strides in the field of immunotherapy, specifically the advancement of Kiromic’s allogeneic outpatient CAR-T for solid tumours. Kiromic’s AI portfolio, which is still developing, will benefit from InSilico’s expertise in the area in further developing AI-based strategies to optimise the response to T cell therapy.
In a recent press release, the company stated that they are “developing models using WGS, RNASeq, scRNASeq, cytometry, and cytokine panels to assist in selecting donor T cells with the strongest therapeutic potential”.
The immunotherapy market of cancer treatment especially is rapidly expanding, with clinical trial results supporting the efficacy of T-cell therapy over conventional treatment. Unfortunately the efficacy of CAR-T is inconsistent across patient populations, hence a number of pharma companies are investing in biomarker research to create targeted solutions.
This particular collaboration may see Kiromic’s CAR-T therapy lead the way in precision immunotherapy, utilising AI to accelerate the process of identifying biomarkers that could determine treatment response.
Upon signing a deal for $25m with Organon, Swiss biopharma ObsEva will receive up to $500 million in upfront and milestone payments for the commercial sale of their drug Ebopipran.
The selective prostaglandin F2 Alpha receptor antagonist has the potential to be a first-in-class therapy for preterm labour in the US. The drug works by reducing inflammation and uterine contraction during birth, and could improve the lives of millions of mothers worldwide who suffer from the condition.
The collaboration between the companies, both of which focus on women’s health, will build upon Organon’s R&D portfolio and hopefully strengthen the path to long-term growth, as highlighted by the CEO in a recent article. Organon is a global healthcare company and spinoff from Merck, created to focus on improving the health of women throughout their lives.
Preterm labour represents a significant unmet clinical need for women across the world, and the value of a development-stage asset like Ebopipran, could set the stage for Organon to become a market leader. In an Organon press release, ObsEva CEO commented how “there are currently no other known compounds in development. That is why we are focused on evaluating this agent in an important area of unmet need”.
Under the terms of agreement, Organon will license the global development, manufacturing and commercial rights to the drug. The agreement promises significant sales-based milestones for commercial launch, approximately $385 million.
Under terms of the agreement, an upfront payment of $14.5 million will enable Ipsen to obtain an exclusive license to research, develop, manufacture and commercialise novel therapeutics targeted to the BCL-2 associated protein (BAX), an effector of apoptosis.
Apoptosis is an organic process of programmed cell death. When this process becomes dysfunctional, it can lead to uncontrollable cellular replication and development of a tumour. BAX is a novel target in the apoptosis cell-signalling pathway, which has shown potential for applications in immunotherapy.
According to a recent article,“BAX activation by small-molecule agonists have been shown to promote apoptosis while sparing healthy cells in vitro and suppress human acute myeloid leukaemia xenografts and increased host survival without toxicity in vivo”.
The collaboration will be focusing on the small-molecule drug BKX-001 for the potential treatment of leukaemia, lymphoma and solid tumours. Ipsen’s strategy is to use this collaboration to strengthen their preclinical oncology pipeline. In a press release, Ipsen’s Executive Vice President and Head of R&D said the partnership will help move the drug into preclinical development “with the goal of achieving a development candidate that can be evaluated for the potential treatment of hematological malignancies and solid tumors”.
A large proportion of current cancer therapies targeting the apoptosis pathway are focusing on checkpoint inhibitors that target PD-L1 and PD-1 (PD = programmed cell death). Targeting BAX in this pathway in apoptosis is not necessarily new, but in the context of oncology remains in the early stages of R&D. Drugs like Eltrombopag which have shown to inhibit BAX-mediated apoptosis support the potential of this target therapy.
This could mean that BAX inhibitors like BKX-001, which is now under the license of Ipsen, may become a competitor in the market of target immunotherapy and may even accelerate precision medicine for patient populations with treatment resistance to current therapies.
Charlotte Di Salvo, Lead Medical Writer
PharmaFeatures
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