Drug Discovery Biology

Drug Discovery Biology February 7, 2024

The Art and Science of Drug Discovery

Understanding why IND candidates fail is crucial for improving the drug development process.

Drug Discovery Biology January 30, 2024

Exploring Pharmacokinetics, Genetics, and Predictive Models

Despite strides in understanding drug metabolism and disposition, DDIs remain a challenge. Predicting vulnerability to DDIs is paramount for averting adverse effects.

Drug Discovery Biology January 24, 2024

RNA Drugs in Precision Medicine

RNA-based therapeutics, exemplified by ASOs, siRNAs, and miRNAs, have emerged as pivotal players in the era of precision medicine.

Drug Discovery Biology November 9, 2023

Discovering Tomorrow: DLOC Biosystems’ Bold Move to Propel Drug Development at Discovery Park, Kent

DLOC Biosystems has strategically chosen Discovery Park, Kent, as the nucleus for its cutting-edge biology facility.

Drug Discovery Biology September 29, 2023

A Drug’s Journey from Targets to Markets: Druggability, Economic Viability, and Gateways to Human Testing

The path from initial hypotheses to potential medicines is paved with questions and challenges that demand rigorous scrutiny and innovative solutions.

Drug Discovery Biology September 28, 2023

Evolving Horizons in Drug Discovery: From Small Molecules to Protein Therapeutics

The world of drug discovery is a captivating journey filled with innovation and progress.

Drug Discovery Biology August 9, 2023

AI-Driven Optimization of Target Discovery: A Multi-Model Approach

By integrating a multitude of data types, AI algorithms are able to unravel intricate molecular interactions and unveil novel avenues for intervention.

Drug Discovery Biology August 8, 2023

AI-Driven Revolution in Target Identification

Artificial Intelligence is rewriting the rulebook for drug discovery, redefining target identification and validation.

Drug Discovery Biology August 7, 2023

Unveiling Therapeutic Avenues: The Intersection of AI and Target Identification in Drug Discovery

The emergence of AI presents a ray of hope, promising to reshape drug discovery through precision target identification.

Drug Discovery Biology August 4, 2023

Advances in In Silico Methods for Designing Kinase Inhibitors as Anticancer Drugs

In silico methods have revolutionized the landscape of kinase inhibitor design as anticancer drugs.

Drug Discovery Biology August 3, 2023

Unraveling the Molecular Pharmacology of Kinase Inhibitor Drugs: A Nexus of Pharmacology and Immunology

The realm of molecular pharmacology in kinase inhibitor drugs bridges the scientific and medical domains, weaving intricate structures, mechanisms, and pathways into the tapestry of targeted therapy.

Drug Discovery Biology August 2, 2023

Kinase Drug Discovery in Oncology: Pioneering Progress, Paradigm Shifts, and Prospects for the Future

The twenty-first century has witnessed a revolutionary transformation in cancer therapy through kinase inhibitors.

Drug Discovery Biology August 1, 2023

Disentangling the Kinase-Immunotherapy Nexus

Kinase inhibitors have shown promising potential in potentiating tumoricidal responses of immunotherapy, offering a multifaceted approach to address immunosuppression in the tumor microenvironment.

Drug Discovery Biology July 31, 2023

Kinase Drug Discovery: Modern Approaches for Precision Therapeutics

Kinase drug discovery has made remarkable progress, with significant strides in inhibitor design and lead compound identification.

Drug Discovery Biology July 18, 2023

Galápagos and NovAliX: Pioneering Drug Discovery Collaboration Fuels Innovation

Galapagos NV and NovAliX have united to power a revolutionary drug discovery collaboration!

Drug Discovery Biology May 1, 2023

Peptide Inhibition Palliates Preclinical Parkinsonism

By inhibiting the α-synuclein-ESCRT interaction, researchers mitigated neurodegeneration in preclinical models.

Drug Discovery Biology April 21, 2023

Unveiling the Nonenzymatic Safety Valve that Regulates Insulin Response

FBPase curtails AKT activation to prevent insulin hyperresponsiveness and regulate insulin sensitivity.

Drug Discovery Biology April 20, 2023

The Role of FNIP1 in Mitochondrial Quality Control

FNIP1 plays an important role in cells’ ability to sense low energy levels, remove damaged mitochondria, and is associated with aging, cancer, and neurodegenerative diseases.

Drug Discovery Biology April 5, 2023

Decoding the Mysteries of Human Olfaction

Researchers have developed the first molecular-level, 3D model of how an odorant triggers a human olfactory receptor, resolving an enduring roadblock in our grasp of olfaction.

Drug Discovery Biology April 4, 2023

Cardiogenesis Unraveled: Using Organoids to Study Human Heart Biology

Organoids, including epicardioids, provide promising insights into human heart development and illnesses. Retinoic acid signaling modifications offer new molecular insights. These advancements can lead to better treatments for heart disorders and other conditions.

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Inside Johnson & Johnson’s External Innovation Engine: Devin Swanson on Translating Integrated Discovery into Strategic Value

From Data to Decision: Shicheng Guo’s Systems Approach to AI-Enabled Drug Development

Digital Stewardship: Governing Access, Transparency, and Accountability in Clinical Data Warehouses