Drug Discovery Biology

Drug Discovery Biology August 4, 2023

Advances in In Silico Methods for Designing Kinase Inhibitors as Anticancer Drugs

In silico methods have revolutionized the landscape of kinase inhibitor design as anticancer drugs.

Drug Discovery Biology August 3, 2023

Unraveling the Molecular Pharmacology of Kinase Inhibitor Drugs: A Nexus of Pharmacology and Immunology

The realm of molecular pharmacology in kinase inhibitor drugs bridges the scientific and medical domains, weaving intricate structures, mechanisms, and pathways into the tapestry of targeted therapy.

Drug Discovery Biology August 2, 2023

Kinase Drug Discovery in Oncology: Pioneering Progress, Paradigm Shifts, and Prospects for the Future

The twenty-first century has witnessed a revolutionary transformation in cancer therapy through kinase inhibitors.

Drug Discovery Biology August 1, 2023

Disentangling the Kinase-Immunotherapy Nexus

Kinase inhibitors have shown promising potential in potentiating tumoricidal responses of immunotherapy, offering a multifaceted approach to address immunosuppression in the tumor microenvironment.

Drug Discovery Biology July 31, 2023

Kinase Drug Discovery: Modern Approaches for Precision Therapeutics

Kinase drug discovery has made remarkable progress, with significant strides in inhibitor design and lead compound identification.

Drug Discovery Biology July 18, 2023

Galápagos and NovAliX: Pioneering Drug Discovery Collaboration Fuels Innovation

Galapagos NV and NovAliX have united to power a revolutionary drug discovery collaboration!

Drug Discovery Biology May 1, 2023

Peptide Inhibition Palliates Preclinical Parkinsonism

By inhibiting the α-synuclein-ESCRT interaction, researchers mitigated neurodegeneration in preclinical models.

Drug Discovery Biology April 21, 2023

Unveiling the Nonenzymatic Safety Valve that Regulates Insulin Response

FBPase curtails AKT activation to prevent insulin hyperresponsiveness and regulate insulin sensitivity.

Drug Discovery Biology April 20, 2023

The Role of FNIP1 in Mitochondrial Quality Control

FNIP1 plays an important role in cells’ ability to sense low energy levels, remove damaged mitochondria, and is associated with aging, cancer, and neurodegenerative diseases.

Drug Discovery Biology April 5, 2023

Decoding the Mysteries of Human Olfaction

Researchers have developed the first molecular-level, 3D model of how an odorant triggers a human olfactory receptor, resolving an enduring roadblock in our grasp of olfaction.

Drug Discovery Biology April 4, 2023

Cardiogenesis Unraveled: Using Organoids to Study Human Heart Biology

Organoids, including epicardioids, provide promising insights into human heart development and illnesses. Retinoic acid signaling modifications offer new molecular insights. These advancements can lead to better treatments for heart disorders and other conditions.

Drug Discovery Biology April 3, 2023

Unlocking Stem Cell Pluripotency Yields Thymic Organoids

Scientists have made thymic organoids from human pluripotent stem cells that look like the human thymus gland, and this may help study thymic development, interactions and create personalized immunotherapies.

Drug Discovery Biology February 8, 2023

Quotient Sciences and the Quest for Quickening Chemical to Clinical

In a continued quest of quickening chemical production to clinical application, Quotient Sciences expands its oral-dosage form formulation development capabilities via its novel Nottingham facility.

Drug Discovery Biology January 20, 2023

Alfa Chemistry Leverages Computational Excellence to Streamline Drug Discovery

Alfa Chemistry remains a global industry leader with its excellent array of computational chemistry services.

Drug Discovery Biology November 24, 2022

Nitrosylation vs PCSK9: Foreshadowing Novel Anticholesterols

Hope for hypercholesterolemia treatment increases with novel pharmacologic discoveries on PCSK9 inhibition.

Medicinal Chemistry & Pharmacology November 23, 2022

Molecular Modeling Advancements Seen in CD ComputaBio’s Latest Software Suites

Latest molecular docking software suites shown to advance computational biology efforts of CD ComputaBio.

Drug Discovery Biology November 21, 2022

Creative Proteomics Offers ADC Characterization as a Service (CaaS) under Pronalyse

Antibody-drug conjugates (ADCs)’ efficacy & safety secured with CaaS offered by Creative Proteomics.

Drug Discovery Biology June 29, 2022

Mitochondria: More than Just Powerhouses

The mitochondria, as the powerhouses of the cell, are inextricably linked to a multitude of disease mechanisms – we discuss them here.

Drug Discovery Biology June 23, 2022

Targeting Intrinsically Disordered Proteins

IDPs are key regulators of signaling and DNA expression mechanisms. Targeting them comes with a host of challenges to overcome.

Drug Discovery Biology February 2, 2022

Phage Therapy: An Alternative Antimicrobial?

Phage therapy for bacterial infections has a long history – yet remains underdeveloped. We highlight the possibilities for its future, and challenges that need to be overcome.

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Precision in Three Dimensions: A Novel Approach to Tumor Resection and Reconstruction of the Femoral Trochanter

Blueprint for the Future: Establishing Rigorous Standards for Medical AI Data

Halides in Focus: A Fluorometric Leap for Clinical Diagnostics